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(E) -Ajoene

(E) -Ajoene is a oxygenated ajoene and organosulfur compound, which can be acquired via allicin decomposing. The polysulfides from garlic can be converted by human red blood cells into hydrogen sulfide (H2S) and allyl glutathione. (E) -Ajoene has been proved to show neuroprotective effects against ischemic damage. (E) -Ajoene is orally active to inhibit lipid peroxidation. (E) -Ajoene increases the number of cresyl violet-positive neurons and decreases the number of reactive gliosis in the CA1 region[1][2].

Product Specifications

CAS Number

[92284-99-6]

UNSPSC

12352100

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Fungal

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/e-ajoene.html

Concentration

42.66 mM * 100 μL in Ethyl acetate

Purity

95

Solubility

10 mM in DMSO

Smiles

O=S(C/C=C/SSCC=C)CC=C

Molecular Formula

C9H14OS3

Molecular Weight

234.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Rakshit D, et al. The Pharmacological Activity of Garlic (Allium sativum) in Parkinson's Disease: From Molecular Mechanisms to the Therapeutic Potential. ACS Chem Neurosci. 2023 Mar 15;14 (6) :1033-1044. |[2]Yoo DY, et al. Neuroprotective effects of Z-ajoene, an organosulfur compound derived from oil-macerated garlic, in the gerbil hippocampal CA1 region after transient forebrain ischemia. Food Chem Toxicol. 2014 Oct;72:1-7.

Shipping Conditions

Blue Ice

Storage Conditions

Solution, -20°C, 2 years

Scientific Category

Natural Products

Clinical Information

No Development Reported

Curated Selection

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