Nipradolol

Nipradolol (KT-210; K-351) is a potent blocker of alpha-1-adrenergic receptors. Nipradolol inhibits the increase of intraocular pressure (IOP) in an albino rabbit model induced by Phenylephrine (HY-B0769) . Nipradolo suppresses the noradrenaline (NA) -induced muscles contraction, also exhibits vasodilator activity on the dog coronary artery[1][2].

Product Specifications

CAS Number

[81486-22-8]

Product Name Alternative

KT 210; K 351; Hypadil

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/nipradolol.html

Solubility

10 mM in DMSO

Smiles

CC(C)NCC(O)COC1=C2C(CC(O[N+]([O-])=O)CO2)=CC=C1

Molecular Formula

C15H22N2O6

Molecular Weight

326.34

References & Citations

[1]3,4-dihydro-8- (2-hydroxy-3-isopropylaminopropoxy) -3-nitroxy-2H-1-benzopyran (K-351) and its denitrated derivative on smooth muscle cells of the dog coronary artery. Br J Pharmacol. 1983 May;79 (1) :285-95. |[2]Nishio K. Alpha-1-adrenoceptor blocking activity of KT-210 (nipradilol ophthalmic solution) on intraocular pressure in the rabbit eye[J]. Nihon Ganka Kiyo (Folia Ophthalmol Jpn), 1999, 50: 655-660.