FX-06

FX-06 (Fibrin-derived peptide Bβ15-42) is a fibrin Bbeta chain-derived peptide. FX-06 binds to VE-cadherin and inhibits leukocyte transmigration and initiates VE-cadherin-mediated signaling. FX-06 can be used in the research of ischemia/reperfusion injury, Dengue shock syndrome (DSS) [1][2][4].

Product Specifications

CAS Number

[88650-17-3]

Product Name Alternative

Fibrin-derived peptide Bβ15-42

UNSPSC

12352209

Target

Dengue Virus; Flavivirus

Type

Peptides

Related Pathways

Anti-infection

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/fx-06.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C(=O)(N1[C@H](C(=O)N2[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(NCC(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)=O)=O)=O)=O)CO)=O)[C@H](CC)C)=O)CCC2)CCC1)[C@H]4N(C([C@@H](NC(=O)[C@H]5N(C([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]6N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]7N(C([C@@H](NC([C@H](CC8=CN=CN8)NC(CN)=O)=O)CCCNC(=N)N)=O)CCC7)CC(C)C)=O)CC(O)=O)=O)CCCCN)=O)CCCCN)=O)CCCNC(=N)N)=O)CCC(O)=O)=O)CCC(O)=O)=O)C)=O)CCC6)CO)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCC5)C)=O)CCC4

Molecular Formula

C133H216N44O38

Molecular Weight

3039.41

References & Citations

[1]Ahrens I, et al. FX-06, a fibrin-derived Bbeta15-42 peptide for the potential treatment of reperfusion injury following myocardial infarction. Curr Opin Investig Drugs. 2009 Sep;10 (9) :997-1003. |[2]Zou F, et al. Identification of novel allosteric inhibitors of mutant isocitrate dehydrogenase 1 by cross docking-based virtual screening. Bioorg Med Chem Lett. 2018 Feb 1;28 (3) :388-393. |[3]Roesner JP, et al. Bbeta15-42 (FX06) reduces pulmonary, myocardial, liver, and small intestine damage in a pig model of hemorrhagic shock and reperfusion. Crit Care Med. 2009 Feb;37 (2) :598-605. |[4]Gröger M, et al. Peptide Bbeta (15-42) preserves endothelial barrier function in shock. PLoS One. 2009;4 (4) :e5391. |[5]Aparna Krishnamoorthy, et al. Fibrinogen β–derived Bβ15-42 peptide protects against kidney ischemia/ reperfusion injury. Blood (2011) 118 (7) : 1934–1942.