TIK-301

TIK-301 (PD-6735) is a chlorinated melatonin derivative and a potent, high-affinity and orally active melatonin MT1 and MT2 receptors agonist with Kis of 0.081 nM and 0.042 nM, respectively. TIK-301 is also a 5-HT2B/5-HT2C receptors antagonist with antidepressant action. TIK-301 has the potential for sleep disorders and other circadian rhythm disorders treatment[1][2][3].

Product Specifications

CAS Number

[118702-11-7]

Product Name Alternative

PD-6735; LY-156735

UNSPSC

12352005

Target

5-HT Receptor; Melatonin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tik-301.html

Solubility

10 mM in DMSO

Smiles

CC(NC[C@@H](C1=CNC2=C1C=C(OC)C(Cl)=C2)C)=O

Molecular Formula

C14H17ClN2O2

Molecular Weight

280.75

References & Citations

[1]Paulis L, et al. Cardiovascular effects of melatonin receptor agonists. Expert Opin Investig Drugs. 2012 Nov;21 (11) :1661-78.|[2]Rivara S, et al. Melatonin receptor agonists: SAR and applications to the treatment of sleep-wake disorders. Curr Top Med Chem. 2008;8 (11) :954-68.|[3] Carocci A, et al. Melatonergic drugs in development. Clin Pharmacol. 2014 Sep 18;6:127-37.