APC 366

APC 366 is a selective inhibitor of mast cell tryptase (Ki=7.1 μM) . APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma[1][2].

Product Specifications

CAS Number

[158921-85-8]

UNSPSC

12352005

Target

Ser/Thr Protease

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/apc-366.html

Purity

99.81

Solubility

10 mM in DMSO

Smiles

OC1=C(C(N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(N)=O)=O)=O)C=CC3=C1C=CC=C3

Molecular Formula

C22H28N6O4

Molecular Weight

440.50

References & Citations

[1]Barrios VE, et al. Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi. Life Sci. 1998;63 (26) :2295-2303. |[2]Krishna MT, et al. Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma. J Allergy Clin Immunol. 2001;107 (6) :1039-1045.