Lexipafant

Lexipafant is a platelet-activating factor (PAF) antagonist that inhibits the inflammatory response and is used in the research of acute pancreatitis.

Product Specifications

CAS Number

[139133-26-9]

Product Name Alternative

BB-882

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Platelet-activating Factor Receptor (PAFR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/lexipafant.html

Solubility

10 mM in DMSO

Smiles

CC1=NC2=CN=CC=C2N1CC3=CC=C(C=C3)S(N(C)[C@@H](CC(C)C)C(OCC)=O)(=O)=O

Molecular Formula

C23H30N4O4S

Molecular Weight

458.57

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Kingsnorth AN, Galloway SW, Formela LJ. Randomized, double-blind phase II trial of Lexipafant, a platelet-activating factor antagonist, in human acute pancreatitis. Br J Surg. 1995;82 (10) :1414-1420. |[2]Galloway SW, Kingsnorth AN. Lung injury in the microembolic model of acute pancreatitis and amelioration by lexipafant (BB-882), a platelet-activating factor antagonist. Pancreas. 1996;13 (2) :140-146.