3,5-Bis(4-nitrophenoxy)benzoic acid
Product Specifications
UNSPSC Description
3,5-Bis(4-nitrophenoxy)benzoic acid is an inhibitor of γ-secretase. 3,5-Bis(4-nitrophenoxy)benzoic acid causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25). 3,5-Bis(4-nitrophenoxy)benzoic acid, as a marker for fetal hypothyroidism, is a 3,3’-diiodothyronine sulfate (T2S) cross-reactive material in maternal serum[1].
Target Antigen
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling;Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/3-5-bis-4-nitrophenoxy-benzoic-acid.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=CC(OC2=CC=C([N+]([O-])=O)C=C2)=CC(OC3=CC=C([N+]([O-])=O)C=C3)=C1
Molecular Weight
396.31
References & Citations
[1]Wu SY, et al. Compound W, a 3,3'-diiodothyronine sulfate cross-reactive substance in serum from pregnant women--a potential marker for fetal thyroid function. Pediatr Res. 2007;61(3):307-312.|[2]Ran Y, et al. Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors. PLoS One. 2015;10(6):e0128619. Published 2015 Jun 5.|[3]Greife A, et al. Canonical Notch signalling is inactive in urothelial carcinoma. BMC Cancer. 2014;14:628. Published 2014 Aug 29.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-103539/3-5-Bis-4-nitrophenoxy-benzoic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-103539/
Clinical Information
No Development Reported
CAS Number
173550-33-9
Curated Selection
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