JLK-6

JLK-6 markedly reduce the production of amyloid β-peptide (Aβ) by amyloid-β Precursor protein (APP) expressing HEK293 cells by affecting the γ-secretase cleavage of APP, with no effect on the cleavage of the Notch receptor[1].

Product Specifications

CAS Number

[62252-26-0]

UNSPSC

12352005

Hazard Statement

H315-H319

Target

Amyloid-β

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/jlk-6.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=CC(N)=CC=C2C(Cl)=C(OC)O1

Molecular Formula

C10H8ClNO3

Molecular Weight

225.63

Precautions

P264-P280-P302+P352-P305+P351+P338-P362+P364

References & Citations

[1]Marine Peuchmaur, et al. Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein. Bioorg Med Chem. 2013 Feb 15;21 (4) :1018-29.