(R, R) -THC

(R, R) -THC is an ERα agonist and an ERβ antagonist, with Kis of 9.0 nM and 3.6 nM for ERα and ERβ, respectively. (R, R) -THC has higher relative binding affinity for ERβ than ERα with the values of 25 and 3.6[1].

Product Specifications

CAS Number

[221368-54-3]

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/r-r-thc.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

OC(C=C1C[C@H]2CC)=CC=C1C3=C2C4=C(C=C(O)C=C4)C[C@H]3CC

Molecular Formula

C22H24O2

Molecular Weight

320.42

References & Citations

[1]Sun J, et al. Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta. Endocrinology. 1999;140 (2) :800-804.