Tocrifluor 1117

Tocrifluor 1117 (T1117), a fluorescent form of the cannabinoid CB1 receptor antagonist AM251 (HY-15443), is a selective fluorescent GPR55 ligand. Tocrifluor 1117 is a potent tool for identifying the cellular location of cannabinoid receptors (including GPR55 in living tissues) (Ex/Em=543/590 nm) [1][2].

Product Specifications

CAS Number

[1186195-59-4]

Product Name Alternative

T1117

UNSPSC

12352005

Target

Cannabinoid Receptor; GPR55

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/tocrifluor-1117.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C(C3=CC=C(C4=CC=C(CCCNC(C5=CC6=C(C7(C8=C(OC9=C7C=CC(N(C)C)=C9)C=C(N(C)C)C=C8)OC6=O)C=C5)=O)C=C4)C=C3)=C1C)NN%10CCCCC%10

Molecular Formula

C56H53Cl2N7O5

Molecular Weight

974.97

References & Citations

[1]Daly CJ, et al. Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries. Br J Pharmacol. 2010 Feb;159 (4) :787-96.|[2]Singh NS, et al. Selective GPR55 antagonism reduces chemoresistance in cancer cells. Pharmacol Res. 2016 Sep;111:757-766.