COR170

COR170 (11u) is a selective CB2 inverse-agonist which is a 4-quinolone-3-carboxylic acid derivative with a Ki value of 3.8 nM for CB2 receptor. COR170 can be used for the research of inflammation and neuroprotection[1][2][3].

Product Specifications

CAS Number

[1048039-15-1]

UNSPSC

12352005

Target

Cannabinoid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cor170.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CN(CCCCC)C2=CC=C(C3=CC=CC=C3)C=C2C1=O)NC45C[C@H](C6)C[C@H](C[C@H]6C5)C4

Molecular Formula

C31H36N2O2

Molecular Weight

468.63

References & Citations

[1]Contartese A, et al. A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury. Pharmacol Res. 2012 Dec;66 (6) :555-63.|[2]Pasquini S, et al. Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo. J Med Chem. 2008 Aug 28;51 (16) :5075-84.|[3]Cascio MG, et al. In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB (2) receptor inverse agonists. Pharmacol Res. 2010 Apr;61 (4) :349-54.