Cl-HIBO

Cl-HIBO is a highly subtype-selective GluR1/2 agonist (EC50=4.7 and 1.7 μM, respectively) . Cl-HIBO is a potent AMPA receptor agonist (IC50=0.22 μM) . Cl-HIBO has desensitizing properties[1].

Product Specifications

CAS Number

[909400-43-7]

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cl-hibo.html

Purity

99.0

Solubility

H2O : 4.5 mg/mL (ultrasonic; warming)

Smiles

O=C(O)C(N)CC(ON1)=C(Cl)C1=O

Molecular Formula

C6H7ClN2O4

Molecular Weight

206.58

References & Citations

[1]Bjerrum EJ, et al. Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS) -2-amino-3- (4-chloro-3-hydroxy-5-isoxazolyl) propionic acid (Cl-HIBO) . J Med Chem. 2003;46 (11) :2246-2249.