Carpindolol

Carpindolol (SDZ21009) is a 5-HT1B receptor antagonist (pKd of 8.53 and pKB of 8.0) and a 5-HT1D receptor agonist (pEC50 of 5.91 and pKd of 6.37) [1].

Product Specifications

CAS Number

[39731-05-0]

Product Name Alternative

SDZ21009

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/carpindolol.html

Solubility

10 mM in DMSO

Smiles

O=C(C(N1)=CC2=C1C=CC=C2OCC(O)CNC(C)(C)C)OC(C)C

Molecular Formula

C19H28N2O4

Molecular Weight

348.44

References & Citations

[1]P Schoeffter, et al. 5-Hydroxytryptamine 5-HT1B and 5-HT1D receptors mediating inhibition of adenylate cyclase activity. Pharmacological comparison with special reference to the effects of yohimbine, rauwolscine and some beta-adrenoceptor antagonists. Naunyn Schmiedebergs Arch Pharmacol. 1989 Sep;340 (3) :285-92.