CV1808

CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with Kis of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively[1].

Product Specifications

CAS Number

[53296-10-9]

Product Name Alternative

2-Phenylaminoadenosine

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Adenosine Receptor; Endogenous Metabolite

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cv1808.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=C2C(N([C@@]3([H])[C@@H]([C@@H]([C@H](O3)CO)O)O)C=N2)=NC(NC4=CC=CC=C4)=N1

Molecular Formula

C16H18N6O4

Molecular Weight

358.35

Precautions

H315, H319, H320

References & Citations

[1]K H Yip, et al. Reciprocal modulation of anti-IgE induced histamine release from human mast cells by A₁ and A (2B) adenosine receptors. Br J Pharmacol. 2011 Sep;164 (2b) :807-19. |[2]I van der Ploeg, et al.Functional characterization of adenosine A2 receptors in Jurkat cells and PC12 cells using adenosine receptor agonists. Naunyn Schmiedebergs Arch Pharmacol.1996 Feb;353 (3) :250-60. |[3]Ming-Guo Feng, et al. Afferent arteriolar vasodilator effect of adenosine predominantly involves adenosine A2B receptor activation. Am J Physiol Renal Physiol. 2010 Aug;299 (2) :F310-5.