Br-PBTC
Br-PBTC is a potent, 2/4 subtype-selective positive allosteric modulator of nAChRs (nicotinic acetylcholine receptors) with α2β2, α2β4, α4β2, α4β4, (α4β2) 2α4 and (α4β2) 2β2 EC50 ranges from 0.1-0.6 μM. Br-PBTC acts from the c-tail of an α subunit[1].
Product Specifications
CAS Number
[1839519-57-1]
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/br-pbtc.html
Purity
98.0
Solubility
DMSO : 2 mg/mL (ultrasonic; warming)
Smiles
O=C(C1=CC2=CC=CC(Br)=C2S1)N[C@H]3CNCCC3
Molecular Formula
C14H15BrN2OS
Molecular Weight
339.25
References & Citations
[1]Wang J, et al. A Novel α2/α4 Subtype-selective Positive Allosteric Modulator of Nicotinic Acetylcholine Receptors Acting from the C-tail of an α Subunit. J Biol Chem. 2015;290 (48) :28834-28846.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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