MK-0674
Product Specifications
UNSPSC Description
MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S[1].
Target Antigen
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/MK-0674.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)[C@H](C1=CC=C(C2=CC=C(C=C2)[C@@H](O)C(F)F)C=C1)N[C@@H](CC(C)(F)C)C(NC3(CC3)C#N)=O
Molecular Weight
527.50
References & Citations
[1]Isabel E, et al. The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor. Bioorg Med Chem Lett. 2010 Feb 1;20(3):887-92.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10290/MK-0674-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10290/
Clinical Information
No Development Reported
CAS Number
887781-62-6
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