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Triciribine phosphate

Product Specifications

UNSPSC Description

Triciribine phosphate (TCN-P) inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate also inhibits  IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity[1].

Target Antigen

ATP Synthase

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/triciribine-phosphate.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

NC1=NN(C)C2=C3C1=CN([C@@H]4O[C@@H]([C@H]([C@H]4O)O)COP(O)(O)=O)C3=NC=N2

Molecular Weight

400.28

References & Citations

[1]E C Moore, Inhibition of two enzymes in de novo purine nucleotide synthesis by triciribine phosphate (TCN-P). Biochem Pharmacol. 1989, 38, 22.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-10250/Triciribine-phosphate-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-10250/Triciribine-phosphate-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

61966-08-3

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