(R) -BMS-816336

(R) -BMS-816336 (Compound 6n-1) is a potent and orally active inhibitor of human, mouse and cynomolgus monkey 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC50s of 14.5 nM, 50.3 nM and 16 nM, respectively [1].

Product Specifications

CAS Number

[1009583-83-8]

UNSPSC

12352005

Target

11β-HSD

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/r-bms-816336.html

Purity

96.57

Solubility

DMSO : 300 mg/mL (ultrasonic)

Smiles

O[C@H]1[C@H]2C[C@@H]3[C@@](C4=CC=CC=C4)(CC(N5CC(O)C5)=O)[C@@H](C[C@H]1C3)C2

Molecular Formula

C21H27NO3

Molecular Weight

341.44

References & Citations

[1]Ye XY, et al. Discovery of Clinical Candidate 2- ((2S,6S) -2-Phenyl-6-hydroxyadamantan-2-yl) -1- (3'-hydroxyazetidin-1-yl) ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. J Med Chem. 2017 Jun 22;60 (12) :4932-4948.