CHMFL-BTK-01

CHMFL-BTK-01 (compound 9) is a highly selective irreversible BTK inhibitor, with an IC50 of 7 nM. CHMFL-BTK-01 (compound 9) potently inhibited BTK Y223 auto-phosphorylation[1].

Product Specifications

CAS Number

[2095280-64-9]

UNSPSC

12352005

Hazard Statement

H302

Target

Btk

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/chmfl-btk-01.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=CC(C(C=C2NC3=CC=C(C(N4CCOCC4)=O)C(NC(C=C)=O)=C3)=CN(C)C2=O)=C1C)C5=CC=C(C(C)(C)C)C=C5

Molecular Formula

C38H41N5O5

Molecular Weight

647.76

Precautions

P264-P270-P330-P501

References & Citations

[1]Liang Q, et al. Discovery of N- (3- (5- ((3-acrylamido-4- (morpholine-4-carbonyl) phenyl) amino) -1-methyl-6-oxo-1,6-dihydropyridin-3-yl) -2-methylphenyl) -4- (tert-butyl) benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor. Eur J Med Chem. 2017 May 5;131:107-125.