BMT-090605

BMT-090605 is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 can be used for the research of neuropathic pain[1].

Product Specifications

CAS Number

[1551403-51-0]

UNSPSC

12352005

Target

AAK1; Cyclin G-associated Kinase (GAK)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bmt-090605.html

Purity

98.27

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#CC1=C(OC[C@@H](N)CC(C)C)C=C(C(C2=CC=NC(C)=C32)=C1)N(C)C3=O

Molecular Formula

C21H24N4O2

Molecular Weight

364.44

References & Citations

[1]Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358 (3) :371-86.