(E/Z) -DMU2105

(E/Z) -DMU2105 (Compound 7k) is a potent and highly selective CYP1B1 inhibitor. (E/Z) -DMU2105 inhibits human CYP1B1 enzyme bound to yeast-derived microsomes with an IC50 value of 10 nM. (E/Z) -DMU2105 also potently inhibits CYP1B1 expressed within ‘live’ recombinant yeast and human HEK293 kidney cells with an IC50 value of 63.65 nM. (E/Z) -DMU2105 can be used for the research of cancer, glaucoma, ischemia and obesity[1].

Product Specifications

CAS Number

[1031063-36-1]

UNSPSC

12352005

Hazard Statement

H315-H319

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e-z-dmu2105.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CN=C1)/C=C/C2=CC=C3C=CC=CC3=C2

Molecular Formula

C18H13NO

Molecular Weight

259.30

Precautions

P264-P280-P302+P352-P305+P351+P338-P362+P364

References & Citations

[1]Horley NJ, et al. Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. Eur J Med Chem. 2017 Mar 31;129:159-174.