(S) -Monastrol

(S) -Monastrol ((+) -Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S) -Monastrol arrests mammalian cells in mitosis with monopolar spindles[1][2].

Product Specifications

CAS Number

[254753-54-3]

Product Name Alternative

(+) -Monastrol

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Kinesin; Mitosis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-monastrol.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C)NC(N[C@H]1C2=CC=CC(O)=C2)=S)OCC

Molecular Formula

C14H16N2O3S

Molecular Weight

292.35

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Marques LA, et al. Antiproliferative activity of monastrol in human adenocarcinoma (MCF-7) and non-tumor (HB4a) breast cells. Naunyn Schmiedebergs Arch Pharmacol. 2016 Dec;389 (12) :1279-1288.|[2]Mayer TU, et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 1999 Oct 29;286 (5441) :971-4.