PP7

PP7 is a potent PB1-PB2 interaction inhibitor with an IC50 of 8.6 μM, and their inhibition against viral polymerase activity (IC50=9.5 μM) . PP7 shows antiviral activities against influenza A virus (IAV), including A (H1N1) pdm09 (EC50=1.4 μM), A (H7N9) and A (H9N2) subtypes[1].

Product Specifications

CAS Number

[433238-84-7]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pp7.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C(N2C(/C(C(N2)=O)=C/C3=CC=C(OCC)C=C3)=O)C=C1Cl

Molecular Formula

C18H14Cl2N2O3

Molecular Weight

377.22

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Yuan S, et al. Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface. Antiviral Res. 2017 Jan;137:58-66.