(E) -3-AP

(E) -3-AP is the E configuration of 3-AP. 3-AP is a potent ribonucleotide reductase inhibitor. 3-AP shows anti-proliferative activity. 3-AP shows anticancer activity in L1210 leukemia model. 3-AP inhibits RR activity and DNA synthesis[1][2].

Product Specifications

CAS Number

[200933-27-3]

Product Name Alternative

(E) -PAN-811; (E) -NSC# 663249; (E) -OCX191

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e-3-ap.html

Solubility

10 mM in DMSO

Smiles

NC1=CC=CN=C1/C=N/NC(N)=S

Molecular Formula

C7H9N5S

Molecular Weight

195.24

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Finch RA, et al. Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP) : an inhibitor of ribonucleotide reductase with antineoplastic activity. Adv Enzyme Regul. 1999;39:3-12. |[2]Enyedy ÉA , et al. Complex formation and cytotoxicity of Triapine derivatives: a comparative solution study on the effect of the chalcogen atom and NH-methylation. Dalton Trans. 2020 Dec 8;49 (46) :16887-16902.