D-Serine-d3

D-Serine-d3 ((R) -Serine-d3) is a deuterium labeled D-Serine (HY-100808) . D-Serine ((R) -Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2][3].

Product Specifications

CAS Number

[1414348-52-9]

Product Name Alternative

(R) -Serine-d3

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; iGluR; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Purity

96.36

Solubility

H2O : 50 mg/mL (ultrasonic; warming)

Smiles

OC([C@@](N)([2H])C([2H])([2H])O)=O

Molecular Formula

C3H4D3NO3

Molecular Weight

108.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-246.|[2]Andrea R. Durrant, et al. D-Serine in Neuropsychiatric Disorders: New Advances.|[3]MacKay MB, et al. D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression Front Psychiatry. 2019 Feb 6;10:25.|[4]Dai X, et al. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10 (1) :1986.|[5]Suwandhi L, et al. Chronic d-serine supplementation impairs insulin secretion. Mol Metab. 2018 Oct;16:191-202.