(+) -Bicuculline (methochloride)

(+) -Bicuculline methobromide is a potent GABAA blocker. (+) -Bicuculline methobromide alters membrane properties and firing pattern. (+) -Bicuculline methobromide reduces the Apamin-sensitive afterhyperpolarization, while Apamin is a toxin isolated from bee venom to block small conductance Ca2+ -activated K+ channels. (+) -Bicuculline methobromide facilitates burst firing via blocking apamin-sensitive Ca2+ -activated K+ current[1].

Product Specifications

CAS Number

[53552-05-9]

UNSPSC

12352005

Hazard Statement

H300-H311-H331-H400

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/minus-bicuculline-methochloride.html

Solubility

10 mM in DMSO

Smiles

C[N+]1([C@](C2=C(CC1)C=C3C(OCO3)=C2)([H])[C@@]4([H])C5=C(C6=C(OCO6)C=C5)C(O4)=O)C.[Cl-]

Molecular Formula

C21H20ClNO6

Molecular Weight

417.84

Precautions

P261-P264-P270-P271-P273-P280-P302+P352-P304+P340-P330-P361+P364-P391-P403+P233-P405-P501

References & Citations

[1]Johnson SW, et al. Bicuculline methiodide potentiates NMDA-dependent burst firing in rat dopamine neurons by blocking apamin-sensitive Ca2+-activated K+ currents. Neurosci Lett. 1997 Aug 1;231 (1) :13-6. |[2]Okazaki R, et al. The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation. Anesth Analg. 2008 Sep;107 (3) :1064-9.|[3]Yang Y, et al. Ketamine blocks bursting in the lateral habenula to rapidly relieve depression[J]. Nature, 2018, 554 (7692) : 317-322. |[4]Sperber EF, et al. Nigral infusions of muscimol or bicuculline facilitate seizures in developing rats. Brain Res. 1987 Dec 15;465 (1-2) :243-50.