Elastatinal

Elastatinal is a potent and competitive inhibitor of elastase, with a Ki of 0.21 μM. Elastatinal more potently inhibits pancreatic elastase versus leucocyte elastase. Elastatinal shows no activity on human leucocyte chymotrypsin-like protease[1][2][3][4].

Product Specifications

CAS Number

[51798-45-9]

UNSPSC

12352005

Target

Elastase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/elastatinal.html

Purity

99.9

Solubility

DMF : 33 mg/mL (ultrasonic; warming)

Smiles

O=C[C@H](C)NC([C@H](CCC(N)=O)NC([C@H]([C@@]1([H])NC(N)=NCC1)NC(N[C@H](C(O)=O)CC(C)C)=O)=O)=O

Molecular Formula

C21H36N8O7

Molecular Weight

512.56

References & Citations

[1]Umezawa H. Structures and activities of protease inhibitors of microbial origin. Methods Enzymol. 1976;45:678-95.|[2]Feinstein G, et, al. The inhibition of human leucocyte elastase and chymotrypsin-like protease by elastatinal and chymostatin. Biochim Biophys Acta. 1976 May 13;429 (3) :925-32.|[3]Sugisaki R, et, al. Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin. Bone. 2020 Mar;132:115216.|[4]Vidhya R, et, al. Anti-inflammatory effects of troxerutin are mediated through elastase inhibition. Immunopharmacol Immunotoxicol. 2020 Oct;42 (5) :423-435.