Tryptophol

Tryptophol is an aromatic alcohol and secondary metabolite produced by microorganisms. Tryptophol induces apoptosis and cleavage of caspase-8. Tryptophol inhibits Cunninghamella blakesleeana biofilm. Tryptophol has anti-phage infection, biofilm formation regulation, anti-inflammatory, hemolytic, sleep induction, temperature change, seizure susceptibility and immune regulation activities. Tryptophol is used in the research of African trypanosomiasis, sleep disorders, epilepsy[1][2][3][4][5][6][7][8][9][10][11][12].

Product Specifications

CAS Number

[526-55-6]

Product Name Alternative

Indole-3-ethanol

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bacterial; Caspase; Endogenous Metabolite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/tryptophol.html

Concentration

10mM

Purity

99.97

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OCCC1=CNC2=CC=CC=C12

Molecular Formula

C10H11NO

Molecular Weight

161.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhao Z, et al. Tryptophol Improves the Biocontrol Efficacy of Scheffersomyces spartinae against the Gray Mold of Strawberries by Quorum Sensing. J Agric Food Chem. 2023 Dec 13;71 (49) :19739-19748.|[2]Kosalec I, et al. Assessment of tryptophol genotoxicity in four cell lines in vitro: a pilot study with alkaline comet assay. Arh Hig Rada Toksikol. 2011 Mar;62 (1) :41-9.|[3]Jin M, et al. The effect of tryptophol on the bacteriophage infection in high-temperature environment. Appl Microbiol Biotechnol. 2015 Oct;99 (19) :8101-11.|[4]Kosalec I, et al. Genotoxicity of tryptophol in a battery of short-term assays on human white blood cells in vitro. Basic Clin Pharmacol Toxicol. 2008 May;102 (5) :443-52.|[5]Inagaki S, et al. Tryptophol induces death receptor (DR) 5-mediated apoptosis in U937 cells. Biosci Biotechnol Biochem. 2007 Aug;71 (8) :2065-8.|[6]Niwa T, et al. In Vitro Anti-inflammatory Activity of Tyrosol and Tryptophol: Metabolites of Yeast via the Ehrlich Pathway. Biol Pharm Bull. 2025;48 (2) :115-118.|[7]Khan MF, et al. Regulation of Cunninghamella spp. biofilm growth by tryptophol and tyrosol. Biofilm. 2021 Mar 26;3:100046.|[8]Seed JR, et al. The biological effects of tryptophol (indole-3-ethanol) : hemolytic, biochemical and behavior modifying activity. Comp Biochem Physiol C Comp Pharmacol. 1978;60 (2) :175-85.|[9]Feldstein A, et al. Tryptophol, 5-hydroxytryptophol and 5-methoxytryptophol induced sleep in mice. Life Sciences, 1970, 9 (6) : 323-329.|[10]FUKUMORI R, et al. Changes in seizure susceptibility after successive treatments of mice with tryptophol and ethanol. Journal of Pharmacy and Pharmacology, 1981, 33 (1) : 586-589.|[11]Satoh T, et al. Effect of tryptophol on pentylenetetrazol and picrotoxin induced convulsion in mice. Life Sci. 1979 May 28;24 (22) :2031-6.|[12]Park I, et al. Gut Microbiota-Derived Indole-3-Carboxylate Influences Mucosal Integrity and Immunity Through the Activation of the Aryl Hydrocarbon Receptors and Nutrient Transporters in Broiler Chickens Challenged With Eimeria maxima. Front Immunol. 2022 Jun 23;13:867754.