P Glycoprotein Recombinant Antibody / MDR1 / ABCB1
Cells selected for resistance to a single cytotoxic drug may become crossresistant to a broad range of drugs with different structures and cellular targets. This phenomenon is called multiple drug resistance (MDR). MDR proteins (Mdrs) are members of a highly conserved superfamily of ATP-binding cassette transport proteins. Mdr-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug-transport pump transporting a variety of drugs from the brain back into the blood. The Mdr-1 gene is known as ABCB1 and is located on human chromosome 7q21.12. The mouse homolog of Mdr-1 is known as Mdr-3. Interestingly, a murine protein by the name of Mdr-1 exists and is encoded by the murine Abcb1b gene, but it is not homologous with human Mdr-1.
Product Specifications
UniProt
P08183
Host
Rabbit
Immunogen
A recombinant partial protein sequence (within amino acids 500-700) from the human protein was used as the immunogen for the P-glycoprotein antibody.
Clonality
Monoclonal
Isotype
IgG κ
Type
Recombinant
Applications
IHC-P
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the P-glycoprotein antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This P-glycoprotein antibody is available for research use only.
CAS Number
9000-83-3
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