ALDH1L1 Antibody
Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH1L1 (aldehyde dehydrogenase 1 family member L1), also known as FTHFD or 10-FTHFD (10-formyltetrahydrofolate dehydrogenase), is a cytosolic protein that is developmentally regulated in the cerebellum. ALDH1L1 binds to folate and catalyzes the conversion of 10-formyltetrahydrofolate (10-FTHF) to tetrahydrofolate (THF) . This suggests a possible role for ALDH1L1 in the regulation of cellular THF levels as well as in the inhibition of cell proliferation (as 10-FTHF is essential for the synthesis of purine) . In addition, the overexpression of ALDH1L1 can restrict cell proliferation in vitro.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
O75891
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 400-600 of human ALDH1L1 protein was used as the immunogen for the ALDH1L1 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
ALDH1L1/7701
Applications
WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the ALDH1L1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ALDH1L1 antibody is available for research use only.
Storage Conditions
Aliquot the ALDH1L1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the ALDH1L1 antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Western blot testing of human SK-BR-3 cell lysate with ADH1L1 antibody (clone ALDH1L1/7701) . Predicted molecular weight ~98 kDa.
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