IL1 beta Antibody / IL1B
Recognizes a protein of 17-31kDa, identified as interleukin 1beta. It shows no cross-reaction with interleukin 1alpha. Epitopes of mAb IL1B/463 and IL1B/4649 are different and provide a good pair for developing an ELISA. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Product Specifications
UniProt
P01584
Host
Mouse
Immunogen
Recombinant human IL1B protein was used as the immunogen for the Interleukin-1 beta antibody.
Clonality
Monoclonal
Isotype
IgG1 κ
Applications
ELISA, IHC-P
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Interleukin-1 beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Interleukin-1 beta antibody is available for research use only.
CAS Number
9007-83-4
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