MSH2 Antibody
Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.
Product Specifications
UniProt
P43246
Host
Mouse
Immunogen
A recombinant partial protein sequence (within amino acids 300-500) from the human protein was used as the immunogen for the MutS homolog 2 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Applications
WB, IHC-P
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the MutS homolog 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MutS homolog 2 antibody is available for research use only.
CAS Number
9007-83-4
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