Topoisomerase II alpha Recombinant Antibody / TOP2A
The topoisomerase II-Alpha isoform is a 170kDa nuclear protein and plays an important role in DNA synthesis and RNA transcription, as well as chromosomal segregation during mitosis. Topoisomerase II-Alpha is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells, and has been shown to be over-expressed in many human cancers. Decreased expression of Topoisomerase II-Alpha is the predominant mechanism of resistance to several chemotherapeutic agents.
Product Specifications
UniProt
P11388
Host
Rabbit
Immunogen
Clonality
Monoclonal
Isotype
IgG κ
Type
Recombinant
Applications
IHC-P
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Topo IIa antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Topo IIa antibody is available for research use only.
Product Datasheet
https://cdn.gentaur.com/products/800/50551392/datasheet/v4496-100ug.pdf
CAS Number
9000-83-3
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