CM010
CM010 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM010 does not inhibit any of the other ALDH family members. CM010 can regulate metabolism and has anti-cancer activity[1].
Product Specifications
CAS Number
[692269-09-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Aldehyde Dehydrogenase (ALDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cm010.html
Purity
99.70
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC1=C(CNC2=NC3=CC=CC=C3N2CCC)C=CC=C1CC=C
Molecular Formula
C20H23N3O
Molecular Weight
321.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Chefetz I, et al. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep. 2019 Mar 12;26 (11) :3061-3075.e6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALDH1
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
