cyclo(CLLFVY)
Product Specifications
UNSPSC Description
cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers[1].
Target Antigen
HIF/HIF Prolyl-Hydroxylase; VEGFR
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cyclo-cllfvy.html
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C(C)C)C(N[C@H]2CC3=CC=C(C=C3)O)=O)=O)=O)=O)[C@H](CS)NC2=O
Molecular Weight
738.94
References & Citations
[1]Miranda E, et al., A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J Am Chem Soc. 2013 Jul 17;135(28):10418-25.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P10426/cyclo-CLLFVY-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P10426/
Clinical Information
No Development Reported
CAS Number
1446322-73-1
Curated Selection
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