APL-1081

APL-1081 (Mal-Exo-EVC-MMAE) is part of an antibody-conjugated active molecule (ADC) . APL-1081 is conjugated with an ADC linker (peptide Mal-Exo-EEVC) and a potent tubulin polymerization inhibitor, MMAE (HY-15162) [1].

Product Specifications

CAS Number

[2921735-80-8]

Product Name Alternative

Mal-Exo-EVC-MMAE

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC; Microtubule/Tubulin

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/apl-1081.html

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OC(C3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)C(NCCCCCN4C(C=CC4=O)=O)=O)=O)=O)=O)=O)OC)=O

Molecular Formula

C75H115N13O19

Molecular Weight

1502.79

References & Citations

[1]Watanabe T, et al. Exo-Cleavable Linkers: Enhanced Stability and Therapeutic Efficacy in Antibody–Drug Conjugates[J]. Journal of Medicinal Chemistry, 2024.