CBR-5884

CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis[1].

Product Specifications

CAS Number

[681159-27-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Phosphoglycerate Dehydrogenase (PHGDH)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CBR-5884.html

Concentration

10mM

Purity

99.02

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C)C(SC#N)=C(NC(C2=CC=CO2)=O)S1)OCC

Molecular Formula

C14H12N2O4S2

Molecular Weight

336.39

Precautions

H315, H319, H335

References & Citations

[1]Edouard Mullarky et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers Proc Natl Acad Sci U S A, 2016 Feb 16, 113 (7) :1778-83.