VT104

VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer[1][2].

Product Specifications

CAS Number

[2417718-25-1]

UNSPSC

12352005

Target

YAP

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vt104.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C2C(C3=CC=C(C(F)(F)F)C=C3)=CC=CC2=C1)N[C@H](C4=NC=CC=C4)C

Molecular Formula

C25H19F3N2O

Molecular Weight

420.43

References & Citations

[1]Tang TT, et, al. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Jun;20 (6) :986-998.|[2]Barry ER, et, al. Recent Therapeutic Approaches to Modulate the Hippo Pathway in Oncology and Regenerative Medicine. Cells. 2021 Oct 11;10 (10) :2715.