U18666A
U18666A, an intra-cellular cholesterol transport inhibitor, inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus[1].
Product Specifications
CAS Number
[3039-71-2]
UNSPSC
12352211
Target
Dengue Virus; Flavivirus; HCV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/U18666A.html
Purity
99.79
Solubility
DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 5.56 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@@]12[C@]3([H])[C@](CC=C1C[C@@H](OCCN(CC)CC)CC2)([H])[C@@]4([H])[C@@](C)(C(CC4)=O)CC3.Cl
Molecular Formula
C25H42ClNO2
Molecular Weight
424.06
References & Citations
[1]Poh MK, et al. U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication. Antiviral Res. 2012 Jan;93 (1) :191-8.|[2]Cenedella RJ, et al. Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes. Lipids. 2009 Jun;44 (6) :477-87.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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