TCL053

TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle[1][2].

Product Specifications

CAS Number

[2361162-70-9]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Liposome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tcl053.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN(C)CCCC(OCC(COC(CCCCCCC/C=C\CCCC)=O)(COC(CCCCCCC/C=C\CCCC)=O)COC(CCCCCCC/C=C\CCCC)=O)=O

Molecular Formula

C53H95NO8

Molecular Weight

874.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Kenjo E, et al. Low immunogenicity of LNP allows repeated administrations of CRISPR-Cas9 mRNA into skeletal muscle in mice. Nat Commun. 2021 Dec 8;12 (1) :7101.|[2]Cationic lipid. JPWO2019131839A1.