Eupatilin

Eupatilin, a lipophilic flavonoid isolated from Artemisia argyi, is a PPARα agonist, and possesses anti-apoptotic, anti-oxidative and anti-inflammatory activities.

Product Specifications

CAS Number

[22368-21-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; PPAR

Type

Natural Products

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology; Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Eupatilin.html

Purity

98.90

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=CC(O)=C(OC)C(O)=C13

Molecular Formula

C18H16O7

Molecular Weight

344.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Jung Y, et al. Eupatilin, an activator of PPARα, inhibits the development of oxazolone-induced atopic dermatitis symptoms in Balb/c mice. Biochem Biophys Res Commun. 2018 Feb 5;496 (2) :508-514.|[2]Jung Y, et al. Eupatilin with PPARα agonistic effects inhibits TNFα-induced MMP signaling in HaCaT cells. Biochem Biophys Res Commun. 2017 Nov 4;493 (1) :220-226.|[3]Du L, et al. Eupatilin prevents H2O2-induced oxidative stress and apoptosis in human retinal pigment epithelial cells. Biomed Pharmacother. 2017 Jan;85:136-140.