MMH2
Product Specifications
UNSPSC Description
MMH2 is a novel BRD4 molecular glue degrader that functions by recruiting the CUL4 and DCAF16 ligases to the second bromodomain of BRD4 (BRD4BD2)[1].
Target Antigen
Epigenetic Reader Domain; Molecular Glues
Type
Reference compound
Related Pathways
Epigenetics;PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mmh2.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(C)SC2=C1C(C3=CC=C(NS(C=C)(=O)=O)C=C3)=N[C@@H](CC(OC(C)(C)C)=O)C4=NN=C(C)N42
Molecular Weight
527.66
References & Citations
[1]Yen-Der Li, et al. Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders. bioRxiv. 2023 Feb 15:2023.02.14.528208.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156828/MMH2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156828/MMH2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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