KT-333 (ammonium)

KT-333 ammonium (Compound A) is a molecular glues that degrades STAT3 protein. KT-333 ammonium mediates the selective degradation of STAT3 through the ubiquitin-proteasome system by binding to STAT3 protein and E3 ubiquitin ligase von Hippel-Lindau protein (VHL) . KT-333 ammonium has strong selectivity for STAT3 protein degradation and good antitumor activity. KT-333 ammonium can be used in the study of hematologic malignancies such as large granular lymphocytic leukemia (LGL-L), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL) [1].

Product Specifications

CAS Number

[2839758-34-6]

UNSPSC

12352005

Target

Molecular Glues; STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; PROTAC; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kt-333-ammonium.html

Purity

99.48

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

ClC(C(CCCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O)=CC=C4)=C4OC[C@H](CCC(N)=O)NC([C@H]5N6[C@](CCN(C[C@@H](C6=O)NC(C7=CC8=CC(C(P(O)(O)=O)=O)=CC=C8N7)=O)C(C)=O)([H])CC5)=O.N

Molecular Formula

C60H77ClN11O14PS

Molecular Weight

1274.81

References & Citations

[1]Phillip CC Liu, et al. A First-in-Class STAT3 Degrader KT-333 in Development for Treatment of Hematologic Cancers. Blood. Volume 138, Supplement 1, 23 November 2021, Page 1865