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Dafadine-A

Dafadine-A is a selective inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans. Dafadine-A inhibits the mammalian ortholog of DAF-9 (CYP27A1) . Dafadine-A does not inhibits DAF-12 and sterol- and oxysterol-metabolizing P450s[1].

Product Specifications

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Dafadine-A.html

Purity

98.94

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1CCC(C2=CC=NC=C2)CC1)C3=NOC(COC4=C(C)C=CC=C4C)=C3

Molecular Formula

C23H25N3O3

Molecular Weight

391.46

References & Citations

[1]Luciani GM, et al. Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans. Nat Chem Biol. 2011 Nov 6;7 (12) :891-3.|[2]Wang X, et al. Cholesterol neutralized vemurafenib treatment by promoting melanoma stem-like cells via its metabolite 27-hydroxycholesterol. Cell Mol Life Sci. 2024 May 22;81 (1) :226.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-16670/Dafadine-A-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-16670/Dafadine-A-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

CAS Number

[1065506-69-5]

Available Sizes

Curated Selection

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