PBITC

PBITC (4-Phenylbutyl isothiocyanate) is an orally active antitumor agent, and inhibits NNK (HY-126477) induced lung tumors in mice. PBITC is a thio-analog of the apoptosis inducer ISC-4 (HY-118375) [1].

Product Specifications

CAS Number

[61499-10-3]

Product Name Alternative

4-Phenylbutyl isothiocyanate

UNSPSC

12352005

Hazard Statement

H302-H312-H315-H319-H332-H334-H335

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pbitc.html

Smiles

S=C=NCCCCC1=CC=CC=C1

Molecular Formula

C11H13NS

Molecular Weight

191.29

Precautions

P261-P264-P270-P271-P280-P284-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Melissa A. Gimbor, et al. Abstract LB-464: Phenylbutyl isoselenocyanate (ISC-4) and phenylbutyl isothiocyanate (PBITC) inhibit 4- (methylnitrosamino) -1- (3-pyridyl) -1-butanone (NNK) induced lung tumorigenesis in A/J mouse. Cancer Res (2011) 71 (8_Supplement) : LB-464.