Zingibroside R1

Zingibroside R1 is dammaranae-type triterpenoid saponin, isolated from rhizomes, taproots, and lateral roots of Panax japonicas C. A. Meyer, shows excellent anti-tumor effects as well as anti-angiogenic activity[1]. Zingibroside R1 possesses some anti-HIV-1 activity. Zingibroside R1 has inhibitory effects on the 2-deoxy-D-glucose (2-DG) uptake by EAT cells (IC50=91.3 μM) [2].

Product Specifications

CAS Number

[80930-74-1]

UNSPSC

12352005

Target

HIV

Type

Natural Products

Related Pathways

Anti-infection

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection; Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/zingibroside-r1.html

Purity

99.75

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@]12C([C@@]3([H])[C@](C(O)=O)(CCC(C)(C)C3)CC2)=CC[C@]4([H])[C@@](C)(CC[C@H](O[C@@]5([H])[C@@H]([C@H]([C@H](O)[C@@H](C(O)=O)O5)O)O[C@]6([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)CO)C7(C)C)[C@@]7([H])CC[C@@]14C

Molecular Formula

C42H66O14

Molecular Weight

794.97

References & Citations

[1]Yoshizaki K, et al. Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus) . Chem Pharm Bull (Tokyo) . 2013;61 (3) :344-50. Epub 2012 Dec 28|[2]Hasegawa H, et al. Inhibitory effect of some triterpenoid saponins on glucose transport in tumor cells and its application to in vitro cytotoxic and antiviral activities. Planta Med. 1994 Jun;60 (3) :240-3.