Cytochalasin J
Product Specifications
UNSPSC Description
Cytochalasin J is a cytochalasin detivative. Cytochalasin J affects mitotic spindel microtubule organization and kinetochore structure, and exhibits cytotoxicity in human leukemia K562 cell with IC50 of 1.5 μM[1][2].
Target Antigen
Microtubule/Tubulin
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cytochalasin-j.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@]12[C@](/C=C/C[C@H](C)C[C@@](C)(O)/C=C/[C@H]2O)([H])[C@@H]3O)N[C@@H](CC4=CC=CC=C4)[C@]1([H])[C@H](C)C3=C
Molecular Weight
451.60
References & Citations
[1]Xu S, et al., Cytotoxic cytochalasin metabolites of endophytic Endothia gyrosa. Chem Biodivers. 2009 May;6(5):739-45.|[2]Wrench GA, et al., Cytochalasin J treatment significantly alters mitotic spindle microtubule organization and kinetochore structure in PtK1 cells. Cell Motil Cytoskeleton. 1997;36(2):112-24.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-126556/Cytochalasin-J-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-126556/
Clinical Information
No Development Reported
CAS Number
53760-20-6
Curated Selection
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