Picenadol

Picenadol (LY-150720) is an opioid mixed agonist-antagonist analgesic. Picenadol is an external racemic mixture, where its d-isomer (LY136596) is a potent μ-opioid receptor agonist, and the l-isomer (LY136595) is a weak μ-receptor competitive antagonist, which can inhibit the agonist effect and reduce the risk of dependence. Picenadol has anticholinergic activity[1][2].

Product Specifications

CAS Number

[79201-85-7]

Product Name Alternative

LY-150720

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/picenadol.html

Solubility

10 mM in DMSO

Smiles

CCC[C@]1([C@@H](C)CN(CC1)C)C2=CC(O)=CC=C2

Molecular Formula

C16H25NO

Molecular Weight

247.38

References & Citations

[1]Carter RB, et al. Effects of LY150720 (picenadol), a novel mixed-action opioid, on schedule-controlled responding in the squirrel monkey. Pharmacol Biochem Behav. 1984 Nov;21 (5) :779-86.|[2]Zimmerman DM, et al. Picenadol. Drug Alcohol Depend. 1985 Feb;14 (3-4) :381-401.