MZ82

MZ82, Ko 143 (HY-10010) derivative, is a ATP-binding cassette subfamily G member 2 (ABCG2/BCRP) inhibitor with the IC50 of ~23 nM. MZ82 not only shows greatly improved metabolic stability over Ko 143 (HY-10010) in liver microsomes but also in mice, and is able to penetrate into the brain[1].

Product Specifications

CAS Number

[2944457-11-6]

UNSPSC

12352005

Target

BCRP

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mz82.html

Smiles

O=C1N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CC(C)C)C4=C(C5=CC=C(OC)C=C5N4)C[C@H]31)=O

Molecular Formula

C26H29N3O3

Molecular Weight

431.53

References & Citations

[1]Yu Q, et al. Modulation of ABCG2 Transporter Activity by Ko143 Derivatives. ACS Chem Biol. 2024 Nov 15;19 (11) :2304-2313.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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