SNX-482

SNX-482, a peptide, is a potent, high affinity, selective and voltage-dependent R-type CaV2.3 channel blocker with an IC50 of 30 nM. SNX-482 has antinociceptive effect[1][2][3].

Product Specifications

CAS Number

[203460-30-4]

UNSPSC

12352209

Target

Calcium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/snx-482.html

Purity

99.0

Solubility

H2O : 0.5 mg/mL (ultrasonic; warming)

Smiles

O=C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](C)C(NCC(N[C@@H](CSSC[C@@H](C(N1[C@@H](CCC1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(NC2)=O)=O)=O)=O)NC3=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC4=CC=C(C=C4)O)C(N[C@@H](CCSC)C(N[C@@H](CC5=CC=CC=C5)C(NCC(NCC(N[C@@H](CSSC[C@@H](C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CC7=CC=CC=C7)C(N[C@@H](CO)C(N[C@H]8CC9=CC=C(C=C9)O)=O)=O)=O)=O)=O)=O)NC2=O)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(N[C@H]3CSSC[C@@H](C(N[C@@H](C)C(N[C@@H](CC%10=CNC%11=CC=CC=C%10%11)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC%12=CC=CC=C%12)C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC8=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN

Molecular Formula

C192H274N52O60S7

Molecular Weight

4495.00

References & Citations

[1]R Newcomb, et al. Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas. Biochemistry. 1998 Nov 3;37 (44) :15353-62.|[2]E Bourinet, et al. Interaction of SNX482 with domains III and IV inhibits activation gating of alpha (1E) (Ca (V) 2.3) calcium channels. Biophys J. 2001 Jul;81 (1) :79-88.|[3]Elizabeth A Matthews, et al. The Cav2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain. Eur J Neurosci. 2007 Jun;25 (12) :3561-9.